Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester
CAS No.:852213-66-2
Molecular Formula:C₁₆H₁₉F₃O₇S
Molecular Weight:412.384
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

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Technology Process of Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

There total 1 articles about Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 852213-67-3
benzyl 4-cyano-4-deoxy-2,3-O-isopropylidene-β-D-arabinopyranoside

: 358-23-6
trifluoromethylsulfonic anhydride

: 852213-66-2
Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

Guidance literature:: With pyridine; In dichloromethane; at -78 - 0 ℃; for 2h;
DOI:10.1002/anie.200502662

Reference yield:

: 852213-66-2
Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

: 151-50-8
potassium cyanide

: 852213-67-3
benzyl 4-cyano-4-deoxy-2,3-O-isopropylidene-β-D-arabinopyranoside

Guidance literature:: With 18-crown-6 ether; 4 A molecular sieve; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1002/anie.200502662

Reference yield:

: 852213-66-2
Trifluoro-methanesulfonic acid (3aS,4R,7S,7aS)-4-benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl ester

: 874353-91-0
(S)-1-((3aS,4S,7R,7aR)-4-Benzyloxy-2,2-dimethyl-tetrahydro-[1,3]dioxolo[4,5-c]pyran-7-yl)-pentylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3.3 g / 4 Angstroem molecular sieves; 18-crown-6 / dimethylformamide / 16 h / 20 °C

2.1: diethyl ether / 2 h / 20 °C

2.2: 74 percent / NaBH₄ / diethyl ether; methanol / 0 - 20 °C

With 18-crown-6 ether; 4 A molecular sieve; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1002/anie.200502662