(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

Base Information

Chemical Name:(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone
CAS No.:1464150-88-6
Molecular Formula:C₂₅H₂₂F₃N₅O
Molecular Weight:465.478
Hs Code.:

Synonyms:(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

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Chemical Property of (4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

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Technology Process of (4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

There total 6 articles about (4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1464153-45-4
(4-(3-iodoimidazo[1,2-a]pyrazin-6-yl)phenyl)(4-methylpiperazin-1-yl)methanone

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1464150-88-6
(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 140 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1464153-43-2
ethyl 4-(3-iodoimidazo[1,2-a]pyrazin-6-yl)benzoate

: 1464150-88-6
(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide monohydrate / methanol; tetrahydrofuran / 12 h

2: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium hydroxide monohydrate; water; potassium carbonate; HATU; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1464153-44-3
4-(3-iodoimidazo[1,2-a]pyrazin-6-yl)benzoic acid

: 1464150-88-6
(4-methylpiperazin-1-yl)(4-(3-(4-(trifluoromethyl)phenyl)imidazo[1,2-a]pyrazin-6-yl)phenyl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / toluene; ethanol / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

With 4-methyl-morpholine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; HATU; In ethanol; N,N-dimethyl-formamide; toluene;