C₁₀H₁₁ClO

Base Information

• Chemical Name: C₁₀H₁₁ClO
• CAS No.: 1216153-80-8
• Molecular Formula: C₁₀H₁₁ClO
• Molecular Weight: 182.65
• Mol file: 1216153-80-8.mol

Synonyms:C₁₀H₁₁ClO

Chemical Property of C₁₀H₁₁ClO

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₀H₁₁ClO

There total 3 articles about C₁₀H₁₁ClO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acrolein (107-02-8,25068-14-8) + o-toluidine (95-53-4) → C10H11ClO (1216153-80-8)

Guidance literature:

o-toluidine; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

With magnesium oxide; sodium hydrogencarbonate; In water; for 0.5h; pH=6 - 7;

acrolein; With copper(II) choride dihydrate; In water; acetone; for 12h;

DOI:10.1016/j.bmcl.2021.128083

Reference yield:

o-toluene-diazonium chloride (2028-34-4) + acrolein (107-02-8,25068-14-8) → C10H11ClO (1216153-80-8)

Guidance literature:

With copper dichloride; In water; acetone;

DOI:10.1007/s10593-010-0537-7

Reference yield:

o-toluidine (95-53-4) → C10H11ClO (1216153-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium nitrite; hydrogenchloride / water / 0.17 h / -5 - 0 °C

2.1: sodium hydrogencarbonate; magnesium oxide / water / pH 6 - 7

2.2: 20 °C / pH 6 - 7

With hydrogenchloride; magnesium oxide; sodium hydrogencarbonate; sodium nitrite; In water; 2.2: |Meerwein Arylation;

DOI:10.1021/acs.jmedchem.5b01517

upstream raw materials:

o-toluene-diazonium chloride

acrolein

o-toluidine

Downstream raw materials:

C₁₆H₁₅N₃S

C₁₇H₁₇N₃S

C₁₈H₁₈N₂OS

C₁₇H₁₅ClN₂S