(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

Base Information

Chemical Name:(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester
CAS No.:269733-23-5
Molecular Formula:C₄₂H₅₄NO₉P
Molecular Weight:747.866
Hs Code.:

Synonyms:(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

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Chemical Property of (S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

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Technology Process of (S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

There total 5 articles about (S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 86302-43-4,35000-38-5
(tert-Butoxycarbonylmethylene)triphenylphosphorane

: 269733-22-4
N,N-Bis(tert-butoxycarbonyl)-L-aspartic acid α-tert-butyl ester

: 269733-23-5
(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃;
DOI:10.1039/a909722h

Reference yield:

: 80963-08-2
N-tert-butoxycarbonyl-L-aspartic acid β-benzyl α-tert-butyl diester

: 269733-23-5
(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 99 percent / DMAP; aq. KHSO₄; NaHCO₃ / acetonitrile / 20 °C

2: 85 percent / H₂ / 10percent Pd/C / ethanol / 20 °C

3: 70 percent / DMAP; DCC / CH₂Cl₂ / 20 °C

With dmap; potassium hydrogensulfate; hydrogen; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; 10percent Pd/C; In ethanol; dichloromethane; acetonitrile;
DOI:10.1039/b010134f

Reference yield:

: 269733-21-3
N,N-Bis(tert-butoxycarbonyl)-L-aspartic acid β-benzyl α-tert-butyl diester

: 269733-23-5
(S)-5-Bis(tert-butoxycarbonyl)amino-2-(triphenylphosphoranylidene)-3-oxohexanedioic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂ / 10percent Pd/C / ethanol / 20 °C

2: 70 percent / DMAP; DCC / CH₂Cl₂ / 20 °C

With dmap; hydrogen; dicyclohexyl-carbodiimide; 10percent Pd/C; In ethanol; dichloromethane;
DOI:10.1039/b010134f