2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene

Base Information

• Chemical Name: 2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene
• CAS No.: 147643-69-4
• Molecular Formula: C₁₄H₁₃FN₂O₂S
• Molecular Weight: 292.334
• Mol file: 147643-69-4.mol

Synonyms:2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene

Chemical Property of 2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene

There total 1 articles about 2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-(chloromethyl)-4-methylthiobenzene (874-87-3) + 2-nitro-4-fluoroaniline (364-78-3) → 2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene (147643-69-4)

Guidance literature:

With iodine; sodium acetate; at 120 ℃; for 12h;

Reference yield: 90.0%

2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene (147643-69-4) → 4-Fluoro-N1-(4-methylsulfanyl-benzyl)-benzene-1,2-diamine (144727-96-8)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; Ambient temperature;

Reference yield:

2-<<<4-(methylthio)phenyl>methyl>amino>-5-fluoronitrobenzene (147643-69-4) → 4-<1-<<4-(methylsulfonyl)phenyl>methyl>-5-fluorobenzimidazol-2-yl>-3,3-dimethylbutanoic acid

Guidance literature:

Multi-step reaction with 4 steps

1: 90 percent / H₂ / Raney nickel / tetrahydrofuran / Ambient temperature

2: triethylamine / CHCl₃ / 2 h / Ambient temperature

3: hydrochloric acid, acetic acid / H₂O / 4 h / Heating

4: 74 percent / chloroperbenzoic acid / methanol / 10 h / Ambient temperature

With hydrogenchloride; hydrogen; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; nickel; In tetrahydrofuran; methanol; chloroform; water;

upstream raw materials:

1-(chloromethyl)-4-methylthiobenzene

2-nitro-4-fluoroaniline

Downstream raw materials:

4-Fluoro-N¹-(4-methylsulfanyl-benzyl)-benzene-1,2-diamine

4-<1-<<4-(methylthio)phenyl>methyl>-5-fluorobenzimidazol-2-yl>-3,3-dimethylbutanoic acid

4-[5-Fluoro-1-(4-methylsulfanyl-benzyl)-1H-benzoimidazol-2-yl]-3,3-dimethyl-butyric acid ethyl ester