2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one

Base Information

Chemical Name:2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one
CAS No.:72337-73-6
Molecular Formula:C₁₄H₁₃BrO₂
Molecular Weight:293.16
Hs Code.:
DSSTox Substance ID:DTXSID40509042
Nikkaji Number:J2.857.240I
Mol file:72337-73-6.mol

Synonyms:72337-73-6;2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one;2-BROMO-1-(6-METHOXY-2-NAPHTHALENYL)-1-PROPANONE;1-Propanone,2-bromo-1-(6-methoxy-2-naphthalenyl)-;6-Methoxy-2-naphthyl propanone;2-Bromo-1-(6-methoxy-2-naphthyl)-1-propanone;SCHEMBL9044944;DTXSID40509042;XCOAABZEUNQHQG-UHFFFAOYSA-N;MFCD09743889;AKOS011240934;2-Bromo-6'-methoxy-2'-propionaphthone;SY358502;2-bromo-1-(6-methoxy-2-naphtyl)-1-propanone;2-bromo-1-(6-methoxy-2-naphthyl)propan-1-one;2-bromo-1-(6-methoxy-2-naphthyl)-propan-1-one;A837499;BOC-(R)-3-AMINO-(6-PHENYL)-5-HEXENOICACID;2-bromanyl-1-(6-methoxynaphthalen-2-yl)propan-1-one

Suppliers and Price of 2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Bromo-6''-methoxy-2''-propionaphthone
50mg
$ 165.00

American Custom Chemicals Corporation
2-BROMO-1-(6-METHOXY-2-NAPHTHALENYL)-1-PROPANONE 95.00%
5MG
$ 498.91

Total 12 raw suppliers

Chemical Property of 2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one

Chemical Property:

Melting Point:78-80 °C(Solv: ethanol (64-17-5))
Boiling Point:392.1±17.0 °C(Predicted)
PSA：26.30000
Density:1.401±0.06 g/cm3(Predicted)
LogP:3.81450
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:292.00989
Heavy Atom Count:17
Complexity:279

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-6''-methoxy-2''-propionaphthone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C(=O)C1=CC2=C(C=C1)C=C(C=C2)OC)Br
Uses 2-Bromo-6''-methoxy-2''-propionaphthone, is an impurity of Naproxen (N377525), an anti-inflammatory, analgesic, and antipyretic.

Technology Process of 2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one

There total 2 articles about 2-Bromo-1-(6-methoxynaphthalen-2-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 2700-47-2
6-methoxy-2-propionylnaphthalene

: 83022-47-3,102849-62-7,107656-29-1,72337-73-6
S(+)-2-bromo-1-(6-methoxy-2-naphthyl)-propan-1-one

Guidance literature:: With pyridinium hydrobromide perbromide; In 1,4-dioxane;
DOI:10.1016/S0040-4039(01)82941-5

Reference yield: 86.9%

: 83022-47-3,102849-62-7,107656-29-1,72337-73-6
S(+)-2-bromo-1-(6-methoxy-2-naphthyl)-propan-1-one

Guidance literature:

Reference yield:

: 83022-47-3,102849-62-7,107656-29-1,72337-73-6
S(+)-2-bromo-1-(6-methoxy-2-naphthyl)-propan-1-one

: 1243257-41-1
2-[3-methyl-2-(6-methoxynaphthalen-2-yl)-morpholino-4-yl]ethyl 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-acetate hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 2 h / 60 °C

2: formic acid / 18 h / 180 °C

3: triethylamine / tetrahydrofuran / 6 h / 20 °C

With formic acid; triethylamine; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 2: Leuckart-Wallach reaction;
DOI:10.1002/cjoc.201200196