5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

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Chemical Name:5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide
CAS No.:1394017-37-8
Molecular Formula:C₂₀H₂₃N₃O₃
Molecular Weight:353.421
Hs Code.:

Synonyms:5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

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Chemical Property of 5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

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Technology Process of 5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

There total 2 articles about 5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.1%

: 1394017-92-5
4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride

: 134541-06-3
5-tert.Butyl-4-isoxazolecarboxylic acid

: 1394017-37-8
5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

Guidance literature:: 5-tert.Butyl-4-isoxazolecarboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.5h; Inert atmosphere;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; With triethylamine; In N,N-dimethyl-formamide; for 16h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.07.032

Reference yield: 66.1%

: 4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride

: 134541-06-3
5-tert.Butyl-4-isoxazolecarboxylic acid

: 1394017-37-8
5-tert-butyl-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)isoxazole-4-carboxamide

Guidance literature:: 5-tert.Butyl-4-isoxazolecarboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.5h;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; With triethylamine; In N,N-dimethyl-formamide; for 16h;