6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

Base Information

Chemical Name:6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine
CAS No.:1356955-65-1
Molecular Formula:C₂₁H₁₈N₄O₂S
Molecular Weight:390.466
Hs Code.:

Synonyms:6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

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Chemical Property of 6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

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Technology Process of 6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

There total 1 articles about 6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 99-81-0
4-Nitrophenacyl bromide

: 2-amino-5-benzyl-4,5,6,7-tetrahydrothiazolo[4,5-c]pyridine

: 1356955-65-1
6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

Guidance literature:: In isopropyl alcohol; Inert atmosphere; Reflux;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1356955-65-1
6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

: 1356955-66-2
2-(4-aminophenyl)-6-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

Guidance literature:: 6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine; With hydrogenchloride; tin(ll) chloride; In methanol; water; for 0.5h; Reflux;

With potassium carbonate; In methanol; water; pH=9;
DOI:10.1016/j.ejmech.2011.10.051

Reference yield:

: 1356955-65-1
6-benzyl-2-(4-nitrophenyl)-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridine

: 1356955-75-3
N-[4-(6-benzyl-5,6,7,8-tetrahydroimidazo[2',1':2,3]thiazolo[5,4-c]pyridin-2-yl)phenyl]-3-[2-(3,5-difluorophenyl)acetamido]propanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; tin(ll) chloride / methanol; water / 0.5 h / Reflux

1.2: pH 9

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0.25 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; tin(ll) chloride; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.ejmech.2011.10.051