3'-<2''-(trifluoromethyl)phenyl>spiro-3-one

Base Information

• Chemical Name: 3'-<2''-(trifluoromethyl)phenyl>spiro-3-one
• CAS No.: 76272-14-5
• Molecular Formula: C₁₇H₁₀F₃NO₃
• Molecular Weight: 333.267
• Mol file: 76272-14-5.mol

Synonyms:3'-<2''-(trifluoromethyl)phenyl>spiro-3-one

Chemical Property of 3'-<2''-(trifluoromethyl)phenyl>spiro-3-one

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3'-<2''-(trifluoromethyl)phenyl>spiro-3-one

There total 1 articles about 3'-<2''-(trifluoromethyl)phenyl>spiro-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methylidenephthalide (3453-63-2) + N-hydroxy-2-(trifluoromethyl)benzene-1-carbonimidoyl chloride (74467-04-2) → 3'-<2''-(trifluoromethyl)phenyl>spiro-3-one (76272-14-5)

Guidance literature:

With triethylamine; hydroquinone; In diethyl ether; at 22 ℃; for 24h;

DOI:10.1021/jo00172a030

Reference yield: 98.0%

3'-<2''-(trifluoromethyl)phenyl>spiro-3-one (76272-14-5) → 2-<3-<2-(trifluoromethyl)phenyl>isoxazol-5-yl>benzoic acid (87413-29-4)

Guidance literature:

With sulfuric acid; In 1,4-dioxane; water; for 1h; Heating;

DOI:10.1021/jo00172a030

Reference yield:

3'-<2''-(trifluoromethyl)phenyl>spiro-3-one (76272-14-5) → N-<2-<3-<2-(trifluoromethyl)phenyl>isoxazol-5-yl>benzoyl>piperidine (87413-30-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / conc. H₂SO₄ / H₂O; dioxane / 1 h / Heating

2: 1.) thionyl chloride / 1.) reflux, 40 min, 2.) CCl₄, CH₂Cl₂, ,30 min

With thionyl chloride; sulfuric acid; In 1,4-dioxane; water;

DOI:10.1021/jo00172a030

upstream raw materials:

3-methylidenephthalide

N-hydroxy-2-(trifluoromethyl)benzene-1-carbonimidoyl chloride

Downstream raw materials:

2-<3-<2-(trifluoromethyl)phenyl>isoxazol-5-yl>benzoic acid

N-<2-<3-<2-(trifluoromethyl)phenyl>isoxazol-5-yl>benzoyl>piperidine