5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

Base Information

Chemical Name:5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester
CAS No.:1268675-74-6
Molecular Formula:C₂₂H₁₄Cl₂F₂N₂O₂S
Molecular Weight:479.334
Hs Code.:

Synonyms:5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

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Chemical Property of 5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

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Technology Process of 5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

There total 8 articles about 5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6165-69-1
Thien-3-ylboronic acid

: 1268682-33-2
2-bromo-5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-1H-imidazole-4-carboxylic acid ethyl ester

: 1268675-74-6
5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 85 ℃; for 7h; Inert atmosphere;

Reference yield:

: 403-16-7
3-chloro-4-fluorobenzoic acid

: 1268675-74-6
5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 23 h / 20 °C

2.1: isopropylmagnesium chloride / tetrahydrofuran / 2.83 h / 0 - 50 °C

2.2: 16.5 h / 0 - 50 °C

3.1: triethylamine; 4-dodecylbenzenesulphonyl azide / toluene / 20 °C

4.1: rhodium (II) octanoate dimer / toluene; 1,2-dichloro-ethane / 80 °C / Inert atmosphere

4.2: 20.5 h / 20 - 50 °C / Cooling with ice

5.1: phosphorus(V) oxybromide / toluene / 44 h / 110 °C

6.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 7 h / 85 °C / Inert atmosphere

With potassium phosphate; isopropylmagnesium chloride; 4-dodecylbenzenesulphonyl azide; triethylamine; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; rhodium (II) octanoate dimer; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; toluene;

Reference yield:

: C₁₀H₆ClFN₂O

: 1268675-74-6
5-(3-chloro-4-fluoro-phenyl)-1-(3-chloro-2-fluoro-phenyl)-2-thiophen-3-yl-1H-imidazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropylmagnesium chloride / tetrahydrofuran / 2.83 h / 0 - 50 °C

1.2: 16.5 h / 0 - 50 °C

2.1: triethylamine; 4-dodecylbenzenesulphonyl azide / toluene / 20 °C

3.1: rhodium (II) octanoate dimer / toluene; 1,2-dichloro-ethane / 80 °C / Inert atmosphere

3.2: 20.5 h / 20 - 50 °C / Cooling with ice

4.1: phosphorus(V) oxybromide / toluene / 44 h / 110 °C

5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 7 h / 85 °C / Inert atmosphere

With potassium phosphate; isopropylmagnesium chloride; 4-dodecylbenzenesulphonyl azide; triethylamine; phosphorus(V) oxybromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; rhodium (II) octanoate dimer; In tetrahydrofuran; 1,4-dioxane; water; 1,2-dichloro-ethane; toluene;