(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

Base Information

Chemical Name:(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol
CAS No.:210235-98-6
Molecular Formula:C₂₈H₄₆O₂Si₂
Molecular Weight:470.843
Hs Code.:

Synonyms:(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

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Chemical Property of (Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

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Technology Process of (Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

There total 15 articles about (Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 210235-96-4
5-(tert-Butyl-dimethyl-silanyloxy)-1-[(Z)-5-(tert-butyl-dimethyl-silanyloxy)-3-methyl-pent-3-en-1-ynyl]-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohexene

: 210235-98-6
(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

Guidance literature:: With Amberlyst 15E; In methanol; at 0 ℃; for 6h;
DOI:10.1016/S0040-4020(98)00334-2

Reference yield:

: 6153-05-5,105-29-3
(Z)-3-methylpent-2-en-4-ynol

: 210235-98-6
(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1: imidazole / dimethylformamide

2: Ph₃P, CuI, BuNH₂ / Pd(OAc)2 / benzene / 17.5 h / Ambient temperature

3: 94 percent / EtMgBr / tetrahydrofuran

4: 77 percent / 2,6-lutidine / CH₂Cl₂

5: 83 percent / Amberlyst 15E / methanol

With 1H-imidazole; 2,6-dimethylpyridine; copper(l) iodide; Amberlyst 15E; ethylmagnesium bromide; N-butylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-1998-1683

Reference yield:

: 50516-66-0
5-Trimethylsilyl-3-methyl-pent-1-en-4-in-3-ol

: 210235-98-6
(Z)-5-[5-(tert-Butyl-dimethyl-silanyloxy)-6,6-dimethyl-5-(3-trimethylsilanylmethyl-but-3-en-1-ynyl)-cyclohex-1-enyl]-3-methyl-pent-2-en-4-yn-1-ol

Guidance literature:: Multi-step reaction with 7 steps

1: K₂CO₃, MeOH

2: H₂O, H₂SO₄

3: imidazole / dimethylformamide

4: Ph₃P, CuI, BuNH₂ / Pd(OAc)2 / benzene / 17.5 h / Ambient temperature

5: 94 percent / EtMgBr / tetrahydrofuran

6: 77 percent / 2,6-lutidine / CH₂Cl₂

7: 83 percent / Amberlyst 15E / methanol

With 1H-imidazole; 2,6-dimethylpyridine; methanol; copper(l) iodide; Amberlyst 15E; sulfuric acid; ethylmagnesium bromide; water; potassium carbonate; N-butylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1055/s-1998-1683