(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

Base Information

Chemical Name:(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione
CAS No.:1613623-37-2
Molecular Formula:C₂₁H₁₉ClN₄O₃S
Molecular Weight:442.926
Hs Code.:

Synonyms:(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

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Chemical Property of (R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

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Technology Process of (R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

There total 8 articles about (R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613623-41-8
11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

: 1613623-36-1
(S)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

: 1613623-37-2
(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

Guidance literature:: With Chiralpak IB 250x10 mm, 5 μm; In methanol; Resolution of racemate;

Reference yield:

: 443667-38-7
5-benzoyl-6-(bromomethyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

: 1613623-36-1
(S)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

: 1613623-37-2
(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / ethanol / 1.33 h / 100 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

2.2: 1.08 h / 0 - 20 °C

3.1: TurboGrignard / tetrahydrofuran / 0.33 h / 20 °C

4.1: sodium tetrahydroborate / methanol / 0.42 h / 20 °C

5.1: triethylamine; trifluoromethylsulfonic anhydride / dichloromethane / 1.75 h / 20 °C

6.1: Chiralpak IB 250x10 mm, 5 μm / methanol / Resolution of racemate

With sodium tetrahydroborate; TurboGrignard; trifluoromethylsulfonic anhydride; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 444058-30-4
5-benzoyl-1,3,6-trimethylpyrimidine-2,4(1H,3H)-dione

: 1613623-36-1
(S)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

: 1613623-37-2
(R)-11-(4-chlorothiazol-2-yl)-1,3-dimethyl-5-phenyl-7,8,10,11-tetrahydropyrimido[4',5':3,4]pyrrolo[1,2-d][1,4]oxazepine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: bromine / chloroform / 2.5 h / 55 °C / Inert atmosphere

2.1: triethylamine / ethanol / 1.33 h / 100 °C / Microwave irradiation

3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C

3.2: 1.08 h / 0 - 20 °C

4.1: TurboGrignard / tetrahydrofuran / 0.33 h / 20 °C

5.1: sodium tetrahydroborate / methanol / 0.42 h / 20 °C

6.1: triethylamine; trifluoromethylsulfonic anhydride / dichloromethane / 1.75 h / 20 °C

7.1: Chiralpak IB 250x10 mm, 5 μm / methanol / Resolution of racemate

With sodium tetrahydroborate; TurboGrignard; trifluoromethylsulfonic anhydride; bromine; sodium hydride; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform;