3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid

Base Information

• Chemical Name: 3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid
• CAS No.: 906565-26-2
• Molecular Formula: C₃₅H₂₈N₂O₈S
• Molecular Weight: 636.682
• Mol file: 906565-26-2.mol

Synonyms:3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid

Chemical Property of 3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid

There total 1 articles about 3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

methyl 1-benzenesulfonylindole-2-acetate + 1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride (380359-50-2) → 3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid (906565-26-2)

Guidance literature:

With titanium tetrachloride; In dichloromethane;

DOI:10.1016/j.tetlet.2006.04.157

Reference yield: 58.0%

3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid (906565-26-2) → {1-benzenesulfonyl-3-[2-formyl-1-(4-methoxy-benzyl)-1H-indole-3-carbonyl]-1H-indol-2-yl}-acetic acid methyl ester (906565-27-3)

Guidance literature:

3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid; With oxalyl dichloride;

With tri-n-butyl-tin hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 20 ℃;

DOI:10.1016/j.tetlet.2006.04.157

Reference yield:

3-(1-benzenesulfonyl-2-methoxycarbonylmethyl-1H-indole-3-carbonyl)-1-(4-methoxy-benzyl)-1H-indole-2-carboxylic acid (906565-26-2) → C29H22N2O4 (906565-29-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (COCl)2

1.2: 58 percent / n-Bu₃SnH / Pd(PPh₃)4 / toluene / 20 °C

2.1: 43 percent / NaH / tetrahydrofuran / 20 °C

3.1: 77 percent / tetrabutylammonium fluoride / tetrahydrofuran

With oxalyl dichloride; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.04.157

upstream raw materials:

1-(4-methoxybenzyl)indole-2,3-dicarboxylic anhydride

Downstream raw materials:

{1-benzenesulfonyl-3-[2-formyl-1-(4-methoxy-benzyl)-1H-indole-3-carbonyl]-1H-indol-2-yl}-acetic acid methyl ester

C₂₉H₂₂N₂O₄

C₃₅H₂₆N₂O₆S