1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile

Base Information

• Chemical Name: 1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile
• CAS No.: 133648-55-2
• Molecular Formula: C₂₂H₂₅NO₅S
• Molecular Weight: 415.51
• Mol file: 133648-55-2.mol

Synonyms:1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile

Chemical Property of 1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile

There total 1 articles about 1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(3,4-dimethoxyphenyl)-4-hydroxy-1-cyclohexanecarbonitrile (69299-13-4) + p-toluenesulfonyl chloride (98-59-9) → 1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile (133648-55-2)

Guidance literature:

With triethylamine; In dichloromethane; at -20 ℃; for 2h;

DOI:10.1021/jm00111a043

Reference yield:

1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile (133648-55-2) → 1-(3,4-dimethoxyphenyl)-c-4--N-methylamino>-r-cyclohexanecarbonitrile (133648-48-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiBr / acetone / 48 h / Heating

2: 52 percent / xylene / 6 h / Heating

With lithium bromide; In acetone; xylene;

DOI:10.1021/jm00111a043

Reference yield:

1-(3,4-dimethoxyphenyl)-c-4-<(p-tolylsulfonyl)oxy>-r-1-cyclohexanecarbonitrile (133648-55-2) → 4-(3,4-dimethoxyphenyl)-4-cyano-1-cyclohexene (133648-60-9)

Guidance literature:

Multi-step reaction with 2 steps

1: LiBr / acetone / 48 h / Heating

2: xylene / 6 h / Heating

With lithium bromide; In acetone; xylene;

DOI:10.1021/jm00111a043

upstream raw materials:

1-(3,4-dimethoxyphenyl)-4-hydroxy-1-cyclohexanecarbonitrile

p-toluenesulfonyl chloride

Downstream raw materials:

1-(3,4-dimethoxyphenyl)-c-4-bromo-r-1-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-t-4-bromo-r-1-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-c-4-iodo-r-1-cyclohexanecarbonitrile

1-(3,4-dimethoxyphenyl)-t-4-iodo-r-1-cyclohexanecarbonitrile