N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Base Information

Chemical Name:N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine
CAS No.:258337-51-8
Molecular Formula:C₃₅H₄₁N₃O₃P₂
Molecular Weight:613.676
Hs Code.:

N<sup>1</sup>,N<sup>8</sup>-Bis(diphenylphosphinoyl)-N<sup>1</sup>,N<sup>4</sup>-methylene-N<sup>8</sup>-(2',3'-epoxypropyl)spermidine

Synonyms:N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Suppliers and Price of N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

There total 3 articles about N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 106-89-8,24969-06-0,13403-37-7
epichlorohydrin

: 258337-50-7
N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylenespermidine

: 258337-51-8
N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Guidance literature:: N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylenespermidine; With sodium hydride; In tetrahydrofuran; for 0.166667h;

epichlorohydrin; In tetrahydrofuran; at 90 ℃; for 6h;
DOI:10.1039/a903293b

Reference yield:

: 124-20-9
N-(3-aminopropyl)-1,4-diaminobutane

: 258337-51-8
N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 60 percent / H₂O / 0.33 h

2.1: 76 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 0 - 20 °C

3.1: NaH / tetrahydrofuran / 0.17 h

3.2: 73 percent / tetrahydrofuran / 6 h / 90 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; water; 1.1: Cyclization / 2.1: Phosphinylation / 3.1: Metallation / 3.2: Ring cleavage;
DOI:10.1039/a903293b

Reference yield:

: 73453-98-2
1-(4-aminobutyl)-1,2,3,4,5,6-hexahydropyrimidine

: 258337-51-8
N¹,N⁸-Bis(diphenylphosphinoyl)-N¹,N⁴-methylene-N⁸-(2',3'-epoxypropyl)spermidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 76 percent / NEt₃ / CH₂Cl₂ / 0.25 h / 0 - 20 °C

2.1: NaH / tetrahydrofuran / 0.17 h

2.2: 73 percent / tetrahydrofuran / 6 h / 90 °C

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Phosphinylation / 2.1: Metallation / 2.2: Ring cleavage;
DOI:10.1039/a903293b