1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

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Chemical Name:1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea
CAS No.:1414551-73-7
Molecular Formula:C₂₉H₃₁N₅O₂
Molecular Weight:481.597
Hs Code.:

Synonyms:1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

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Chemical Property of 1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

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Technology Process of 1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

There total 6 articles about 1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 5356-71-8
1,3-diphenyl-1H-pyrazol-5-amine

: (3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-amine dihydrochioride

: 530-62-1
1,1'-carbonyldiimidazole

: 1414551-73-7
1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

Guidance literature:: 1,3-diphenyl-1H-pyrazol-5-amine; 1,1'-carbonyldiimidazole; In chloroform; at 60 ℃; for 4h;

(3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-amine dihydrochioride; In chloroform; at 100 ℃; for 15h;

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 1414551-73-7
1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

1.2: 3 h / -78 - 20 °C

2.1: trifluoroacetic acid / toluene / 3 h / 5 - 20 °C

3.1: water; lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1.17 h / 0 °C

3.2: 0 - 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 20 °C / Reflux

4.2: 15 h / Reflux

5.1: trifluoroacetic acid / 17 h / 60 °C

6.1: chloroform / 4 h / 60 °C

6.2: 15 h / 100 °C

With diphenyl phosphoryl azide; water; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; toluene;

Reference yield:

: 155835-37-3
(4R)-3-(3-phenyl-2-(E)-propenoyl)-4-phenyl-2-oxazolidinone

: 1414551-73-7
1-(1,3-diphenyl-1H-pyrazol-5-yl)-3-((3S,4R)-1-(2-methoxyethyl)-4-phenylpyrrolidin-3-yl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / toluene / 3 h / 5 - 20 °C

2.1: water; lithium hydroxide; dihydrogen peroxide / tetrahydrofuran / 1.17 h / 0 °C

2.2: 0 - 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 20 °C / Reflux

3.2: 15 h / Reflux

4.1: trifluoroacetic acid / 17 h / 60 °C

5.1: chloroform / 4 h / 60 °C

5.2: 15 h / 100 °C

With diphenyl phosphoryl azide; water; dihydrogen peroxide; triethylamine; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; chloroform; toluene;