-glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester

Base Information

• Chemical Name: -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester
• CAS No.: 134558-00-2
• Molecular Formula: C₃₇H₄₆N₄O₆
• Molecular Weight: 642.795

Synonyms:-glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester

Chemical Property of -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester

There total 2 articles about -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester (134557-99-6) → -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester (134558-00-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / aq. LiOH / tetrahydrofuran / 25 h / 0 - 20 °C

2: 1.) 1-hydroxybenzotriazole hydrate (HOBt), N,N'-dicyclohexylcarbodimide (DCC), 2.) 4-dimethylaminopyridine, Et₃N / 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 72 h

With dmap; lithium hydroxide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran;

DOI:10.1016/0223-5234(93)90078-S

Reference yield:

glycine ethyl ester hydrochloride (623-33-6) + PD 135666 (134557-41-8) → -glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester (134558-00-2)

Guidance literature:

With dmap; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction; 1.) EtOAc, RT, 1 h, 2.) EtOAc, RT, 72 h;

DOI:10.1016/0223-5234(93)90078-S

Reference yield: 73.0%

-glycine N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-1-oxo-4-phenylbutyl>ethyl ester (134558-00-2) → -N-<3-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>amino>-4-phenylbutyl>glycine

Guidance literature:

With sodium hydroxide; In ethanol; at 0 - 20 ℃; for 5.5h;

DOI:10.1016/0223-5234(93)90078-S

upstream raw materials:

glycine ethyl ester hydrochloride

PD 135666

-benzenebutanoic acid β-<<3-(1H-indol-3-yl)-2-methyl-1-oxo-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>amino>methyl ester

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