N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

Base Information

Chemical Name:N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine
CAS No.:203795-49-7
Molecular Formula:C₄₄H₇₈N₁₀O₃
Molecular Weight:795.169
Hs Code.:

N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

Synonyms:N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

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Chemical Property of N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

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Technology Process of N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

There total 11 articles about N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1184-90-3
aminoiminomethanesulfonic acid

: 203795-47-5
Benzyl-methyl-{(R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-tris-(3-amino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl]-pentyl}-amine

: 203795-49-7
N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

Guidance literature:: In methanol; chloroform; at 20 ℃; for 24h;

Reference yield:

: 3758-71-2
3α,7α,12α-trihydroxycholan-24-ol

: 203795-49-7
N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

Guidance literature:: Multi-step reaction with 10 steps

1: 90 percent / Et₃N / dimethylformamide

2: 96 percent / NaH / tetrahydrofuran

3: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

4: 99 percent / Et₃N / CH₂Cl₂

5: 95 percent / NaN₃ / dimethylsulfoxide

6: 95 percent / TsOH / methanol

7: 97 percent / Et₃N / CH₂Cl₂

8: 96 percent

9: 99 percent / LiAlH₄ / tetrahydrofuran

10: 89 percent / methanol

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; sodium azide; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r

Reference yield:

: 1448-36-8
methyl cholate

: 203795-49-7
N-{3-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-17-[(R)-4-(Benzyl-methyl-amino)-1-methyl-butyl]-3,7-bis-(3-guanidino-propoxy)-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-12-yloxy]-propyl}-guanidine

Guidance literature:: Multi-step reaction with 11 steps

1: 98 percent / LiAlH₄ / tetrahydrofuran

2: 90 percent / Et₃N / dimethylformamide

3: 96 percent / NaH / tetrahydrofuran

4: 1.) 9-BBN, 2.) H₂O₂, NaOH / 1.) THF

5: 99 percent / Et₃N / CH₂Cl₂

6: 95 percent / NaN₃ / dimethylsulfoxide

7: 95 percent / TsOH / methanol

8: 97 percent / Et₃N / CH₂Cl₂

9: 96 percent

10: 99 percent / LiAlH₄ / tetrahydrofuran

11: 89 percent / methanol

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; sodium azide; dihydrogen peroxide; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/ja973881r