N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Base Information

Chemical Name:N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine
CAS No.:1288960-68-8
Molecular Formula:C₂₈H₃₉N₃O₅
Molecular Weight:497.635
Hs Code.:

N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Synonyms:N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

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Chemical Property of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

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Technology Process of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

There total 8 articles about N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50675-18-8
3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde

: 1288960-66-6
3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine

: 1489-69-6
Cyclopropanecarboxaldehyde

: 1288960-68-8
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde; 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methylpyrazolo[5,1-b][1,3]oxazole-7-amine; With 2-picoline borane complex; acetic acid; In methanol; at 35 ℃; for 0.5h; Cooling with ice;

Cyclopropanecarboxaldehyde; With 2-picoline borane complex; In methanol; at 10 - 35 ℃; for 2.5h;

With water; sodium hydrogencarbonate; In methanol;

Reference yield:

: 1288961-19-2
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]propan-1-one

: 1288960-68-8
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice

1.2: 0.5 h / 0 - 35 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3.1: toluene-4-sulfonic acid / 4 h / 160 °C / 2250.23 Torr / Microwave irradiation

4.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

5.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 760.05 Torr

6.1: acetic acid; 2-picoline borane complex / methanol / 0.5 h / 35 °C / Cooling with ice

6.2: 2.5 h / 10 - 35 °C

With hydrogenchloride; 2-picoline borane complex; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; sodium nitrite; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1288961-21-6
1-[2,6-dimethoxy-4-(methoxymethyl)phenyl]propan-1-ol

: 1288960-68-8
N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-ethyl-2-methyl-N-(tetrahydro-2H-pyran-4-ylmethyl)pyrazolo[5,1-b][1,3]oxazole-7-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 15 h / 10 - 35 °C / Molecular sieve

2.1: triethylamine / tetrahydrofuran / 0.33 h / Cooling with ice

2.2: 0.5 h / 0 - 35 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4.1: toluene-4-sulfonic acid / 4 h / 160 °C / 2250.23 Torr / Microwave irradiation

5.1: hydrogenchloride; sodium nitrite / water / 0.5 h / Cooling with ice

6.1: hydrogen / 5% Pd(II)/C(eggshell) / ethyl acetate / 1 h / 760.05 Torr

7.1: acetic acid; 2-picoline borane complex / methanol / 0.5 h / 35 °C / Cooling with ice

7.2: 2.5 h / 10 - 35 °C

With hydrogenchloride; tetrapropylammonium perruthennate; 2-picoline borane complex; hydrogen; caesium carbonate; toluene-4-sulfonic acid; acetic acid; 4-methylmorpholine N-oxide; triethylamine; sodium nitrite; 5% Pd(II)/C(eggshell); In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;