(1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester
• CAS No.: 146476-35-9
• Molecular Formula: C₂₂H₃₀NO₂P
• Molecular Weight: 371.459

Synonyms:(1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

Chemical Property of (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

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Technology Process of (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester

There total 14 articles about (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-N-tert-butoxycarbonyl-2-amino-3-methylbutyl-1-diphenylphosphine-borane → (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester (146476-35-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; In toluene; at 40 ℃; for 12h;

DOI:10.1016/S0957-4166(01)00137-9

Reference yield: 96.0%

(S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate (122818-28-4) + potassium diphenylphosphine (15475-27-1,4346-39-8) → (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester (146476-35-9)

Guidance literature:

In tetrahydrofuran; at -35 ℃; for 4h;

DOI:10.1016/S0957-4166(97)00482-5

Reference yield: 84.0%

di-tert-butyl dicarbonate (24424-99-5) + (2S)-1-(diphenylphosphino)-3-methylbutan-2-amine (146476-37-1,1400149-69-0) → (1S)-[1-[(diphenylphosphino)methyl]-2-methylpropyl]carbamic acid 1,1-dimethylethyl ester (146476-35-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol103145g

upstream raw materials:

(S)-2-(N-tert-butoxycarbonylamino)-3-methylbutyl tosylate

diphenylphosphane

potassium diphenylphosphine

(S)-valinol

Downstream raw materials:

(2S)-1-(diphenylphosphino)-3-methylbutan-2-amine

{(S)-1-[(Diphenylphosphanyl)-methyl]-2-methyl-propyl}-isopropylidene-amine

(S)-N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-methyl-benzamide

N-{1-[(diphenylphosphanyl)-methyl]-2-methyl-propyl}-N-isopropyl-formamide

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