ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate
CAS No.:1361451-01-5
Molecular Formula:C₂₈H₄₉IN₄O₅Si₂
Molecular Weight:704.796
Hs Code.:

Synonyms:ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

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Chemical Property of ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

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Technology Process of ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

There total 8 articles about ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361451-00-4
ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

: 1361451-01-5
ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

Guidance literature:: With N-iodo-succinimide; In acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 1489-97-0
ethyl 1,4-dioxaspiro[4.5]decane-8-carboxylate

: 1361451-01-5
ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: -78 - 20 °C

1.3: 6 h / 70 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

3.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 16 h / 80 °C

4.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

5.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 16 h / 50 °C / 760.05 Torr

5.2: 24 h / Reflux

6.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

With potassium phosphate; N-iodo-succinimide; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile;

Reference yield:

: 17159-79-4
ethyl 4-oxocyclohexane-1-carboxylate

: 1361451-01-5
ethyl 4-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)-3-iodopyrazolo[1,5-a]pyrimidin-5-yl)-1-(hydroxymethyl)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: toluene-4-sulfonic acid / benzene / Reflux

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: -78 - 20 °C

2.3: 6 h / 70 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

3.2: -78 - 20 °C

4.1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene / 1,4-dioxane / 16 h / 80 °C

5.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 16 h / 90 °C

6.1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 16 h / 50 °C / 760.05 Torr

6.2: 24 h / Reflux

7.1: N-iodo-succinimide / acetonitrile / 0.5 h / 20 °C

With potassium phosphate; N-iodo-succinimide; hydrogen; potassium acetate; lithium diisopropyl amide; 1,1'-bis-(diphenylphosphino)ferrocene; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; toluene-4-sulfonic acid; In tetrahydrofuran; 1,4-dioxane; water; acetonitrile; benzene;