3-Chloro-4-methylbenzhydrazide

Base Information

• Chemical Name: 3-Chloro-4-methylbenzhydrazide
• CAS No.: 72198-84-6
• Molecular Formula: C₈H₉ClN₂O
• Molecular Weight: 184.625
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID40392517
• Wikidata: Q82190836
• Mol file: 72198-84-6.mol

Synonyms:3-chloro-4-methylbenzohydrazide;72198-84-6;3-Chloro-4-methylbenzhydrazide;Benzoic acid, 3-chloro-4-methyl-, hydrazide;DTXSID40392517;OHBMRZPOTYXXSN-UHFFFAOYSA-N;MFCD03215573;STK667868;AKOS000369902;LS-08879;CS-0118365;FT-0682156;D86486

Chemical Property of 3-Chloro-4-methylbenzhydrazide

Chemical Property:

• Melting Point: 180-182°C
• Refractive Index: 1.582
• PSA: 55.12000
• Density: 1.271g/cm³
• LogP: 2.34310
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 184.0403406
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloro-4-methylbenzohydrazide ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C=C(C=C1)C(=O)NN)Cl

Technology Process of 3-Chloro-4-methylbenzhydrazide

There total 3 articles about 3-Chloro-4-methylbenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-4-methyl-benzoyl chloride (21900-30-1) → C8H9ClN2O (72198-84-6)

Guidance literature:

With sodium hydroxide; hydrazine; In ethanol; water; at -10 ℃; Dean-Stark; Autoclave;

DOI:10.1039/c5ra08910g

Reference yield:

3-chloro-4-methylbenzoic acid (5162-82-3) → C8H9ClN2O (72198-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / Reflux

2: hydrazine hydrate / Reflux

With hydrazine hydrate; sulfuric acid;

DOI:10.1039/c8ra00161h

Reference yield:

3-chloro-4-methyl-benzoic acid ethyl ester (99500-36-4) → C8H9ClN2O (72198-84-6)

Guidance literature:

With hydrazine hydrate; Reflux;

DOI:10.1039/c8ra00161h

upstream raw materials:

3-chloro-4-methyl-benzoyl chloride

3-chloro-4-methyl-benzoic acid ethyl ester

3-chloro-4-methylbenzoic acid

Refernces

• 1、 Xu,Wang,Luo,Yu,Guo,Fu,Zhao,Wu. "Design, synthesis, insecticidal activity and 3D-QSR study for novel trifluoromethyl pyridine derivatives containing an 1,3,4-oxadiazole moiety". . p. 6306 - 6314. Retrieved 2018/02/19.