1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE

Base Information

• Chemical Name: 1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE
• CAS No.: 756895-72-4
• Molecular Formula: C₈H₄ClF
• Molecular Weight: 154.571
• Mol file: 756895-72-4.mol

Synonyms:1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE

Chemical Property of 1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE

Chemical Property:

• Vapor Pressure: 0.933mmHg at 25°C
• Refractive Index: 1.539
• Boiling Point: 185.948°C at 760 mmHg
• Flash Point: 67.022°C
• PSA: 0.00000
• Density: 1.25g/cm³
• LogP: 2.46040

Purity/Quality:

95% ^*data from raw suppliers

1-Chloro-4-ethynyl-2-fluorobenzene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE

There total 1 articles about 1-CHLORO-4-ETHYNYL-2-FLUORO-BENZENE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-chloro-4-ethynyl-2-fluorobenzene (756895-72-4)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 0.166667h;

In methanol; at 20 ℃; for 3h;

Reference yield:

2-iodophenylamine (615-43-0) + 1-chloro-4-ethynyl-2-fluorobenzene (756895-72-4) → 2-((4-chloro-3-fluorophenyl)ethynyl)aniline

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.9b04241

Reference yield:

2-iodophenylamine (615-43-0) + 1-chloro-4-ethynyl-2-fluorobenzene (756895-72-4) → 3-(2-(4-chloro-3-fluorophenyl)-1H-indol-1-yl)isobenzofuran-1(3H)-one

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 24 h / 20 °C / Inert atmosphere

2: palladium diacetate / toluene / 6 h / 10 °C / Sealed tube

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium diacetate; triethylamine; In toluene;

DOI:10.1021/acs.orglett.9b04241

Refernces