(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

Base Information

Chemical Name:(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester
CAS No.:855231-15-1
Molecular Formula:C₄₀H₅₁FN₂O₅Si
Molecular Weight:686.939
Hs Code.:

(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

Synonyms:(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

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Chemical Property of (3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

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Technology Process of (3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

There total 1 articles about (3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 950598-97-7
(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-oxo-hept-6-enoic acid methyl ester

: 855231-13-9
(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-oxo-heptanoic acid methyl ester

: 855231-15-1
(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield: 69.0%

: 855231-15-1
(3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester

: (4R)-4-(4-fluorophenyl)-5-[2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid phenylamide

Guidance literature:: (3R)-3-(tert-butyldimethylsilanyloxy)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-5-hydroxyheptanoic acid methyl ester; With hydrogen fluoride; In water; acetonitrile; at 0 - 20 ℃; for 1h;

With sodium hydrogencarbonate; In water; acetonitrile;