(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Base Information

Chemical Name:(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide
CAS No.:866227-29-4
Molecular Formula:C₂₄H₃₃N₃O₄
Molecular Weight:427.544
Hs Code.:

Synonyms:(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

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Chemical Property of (5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

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Technology Process of (5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

There total 3 articles about (5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 96-32-2
bromoacetic acid methyl ester

: 162536-41-6
(2R,3S)-1-(benzylamino)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol

: 866227-29-4
(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: bromoacetic acid methyl ester; (2R,3S)-1-(benzylamino)-3-[N-(tert-butyloxycarbonyl)amino]-4-phenylbutan-2-ol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

With ammonia; In methanol; at 20 ℃;
DOI:10.1016/j.bmc.2005.06.048

Reference yield:

: 98760-08-8,98818-34-9,98818-35-0,103127-56-6,98737-29-2
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

: 866227-29-4
(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / propan-2-ol / 50 °C

2.1: K₂CO₃ / dimethylformamide / 20 °C

2.2: 96 percent / ammonia / methanol / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2005.06.048

Reference yield:

: 100-46-9
benzylamine

: 866227-29-4
(5R,6S)-3-aza-3-benzyl-6-[(tert-butyloxycarbonyl)amino]-5-hydroxy-7-phenylheptanoyl amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / propan-2-ol / 50 °C

2.1: K₂CO₃ / dimethylformamide / 20 °C

2.2: 96 percent / ammonia / methanol / 20 °C

With potassium carbonate; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.bmc.2005.06.048