4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile
CAS No.:1354948-13-2
Molecular Formula:C₁₁H₇ClF₃N₅
Molecular Weight:301.658
Hs Code.:

Synonyms:4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

Chemical Property:

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Technology Process of 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

There total 5 articles about 4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1354948-12-1
4-[5-(hydroxymethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

: 1354948-13-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 25 ℃; for 2h; Inert atmosphere; Cooling with ice;

Reference yield:

: 852569-35-8
4-amino-5-iodo-2-(trifluoromethyl)benzonitrile

: 1354948-13-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 100 °C / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C

3: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

4: lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

5: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere; Cooling with ice

With thionyl chloride; lithium hydroxide monohydrate; trimethylsilylazide; di-isopropyl azodicarboxylate; potassium carbonate; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1354948-10-9
2-{[4-cyano-2-methyl-5-(trifluoromethyl)phenyl]amino}-2-oxoethyl acetate

: 1354948-13-2
4-[5-(chloromethyl)-1H-tetrazol-1-yl]-5-methyl-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trimethylsilylazide; triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

2: lithium hydroxide monohydrate / tetrahydrofuran / 1.5 h / 20 °C / Cooling with ice

3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / 25 °C / Inert atmosphere; Cooling with ice

With thionyl chloride; lithium hydroxide monohydrate; trimethylsilylazide; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;