(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

Base Information

Chemical Name:(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide
CAS No.:918413-77-1
Molecular Formula:C₁₉H₃₇NO₃SSi
Molecular Weight:387.659
Hs Code.:

Synonyms:(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

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Technology Process of (+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

There total 3 articles about (+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3-methoxymethoxy-1-(trimethylsilyl)allenylzinc bromide

: (S)-N-(cyclohexylmethylene)-2-methylpropane-2-sulfinamide

: 918413-77-1
(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -80 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tetasy.2010.04.044

Reference yield:

: 2043-61-0
cyclohexanecarbaldehyde

: 918413-77-1
(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: PPTS; MgSO₄ / CH₂Cl₂ / 20 °C

2: diethyl ether; hexane; cyclohexane / 1 h / -80 °C

With pyridinium p-toluenesulfonate; magnesium sulfate; In diethyl ether; hexane; dichloromethane; cyclohexane;
DOI:10.1055/s-2007-965989

Reference yield:

: 3-methoxymethoxy-1-(trimethylsilyl)allenylzinc bromide

: 623169-05-1
(E)-(S)-2-methyl-propane-2-sulfinic acid 1-cyclohexyl-methylideneamide

: 918413-77-1
(+)-N-[(1R,2S)-1-cyclohexyl-2-(methoxymethoxy)-4-(trimethylsilyl)but-3-ynyl]-2-methylpropane-2-sulfinamide

: C₁₉H₃₇NO₃SSi

: C₁₉H₃₇NO₃SSi

Guidance literature:: In diethyl ether; hexane; cyclohexane; at -80 ℃; for 1h; Title compound not separated from byproducts.;
DOI:10.1055/s-2007-965989