3-phenylpropionic acid 2-oxocyclohexylmethyl ester

Base Information

Chemical Name:3-phenylpropionic acid 2-oxocyclohexylmethyl ester
CAS No.:327620-68-8
Molecular Formula:C₁₆H₂₀O₃
Molecular Weight:260.333
Hs Code.:

Synonyms:3-phenylpropionic acid 2-oxocyclohexylmethyl ester

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Chemical Property of 3-phenylpropionic acid 2-oxocyclohexylmethyl ester

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Technology Process of 3-phenylpropionic acid 2-oxocyclohexylmethyl ester

There total 2 articles about 3-phenylpropionic acid 2-oxocyclohexylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 5331-08-8
2-(hydroxymethyl)cyclohexanone

: 501-52-0
3-Phenylpropionic acid

: 327620-68-8
3-phenylpropionic acid 2-oxocyclohexylmethyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1021/jo005665y

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 327620-68-8
3-phenylpropionic acid 2-oxocyclohexylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / K₂CO₃ / H₂O / 1 h

2: 83 percent / DMAP; EDCI / CH₂Cl₂ / 15 h / 20 °C

With dmap; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water;
DOI:10.1021/jo005665y

Reference yield:

: 327620-68-8
3-phenylpropionic acid 2-oxocyclohexylmethyl ester

: (2-methyl-2-phenethyl-hexahydro-benzo[1.3]dioxin-8a-yl)methanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLo / tetrahydrofuran / 0.5 h / 0 °C

1.2: tetrahydrofuran / 1 h / -78 °C

2.1: 0.62 g / m-CPBA / CH₂Cl₂ / 4 h / 0 °C

3.1: 90 percent / AgClO₄ / Cp₂ZrCl₂ / CH₂Cl₂ / 0 °C

4.1: 57 percent / toluene; diethyl ether / 0.5 h / 20 °C

With n-butyllithium; silver perchlorate; 3-chloro-benzenecarboperoxoic acid; zirconocene dichloride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 1.2: Wittig reaction;
DOI:10.1021/jo005665y