methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Base Information

• Chemical Name: methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate
• CAS No.: 909897-09-2
• Molecular Formula: C₂₁H₁₉F₃N₂O₅S
• Molecular Weight: 468.453
• Mol file: 909897-09-2.mol

Synonyms:methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Chemical Property of methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate

There total 4 articles about methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate (907587-49-9) + N-methylpyrrole-3-sulfonyl chloride → methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate (909897-09-2)

Guidance literature:

With pyridine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2006.05.076

Reference yield:

methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate (907587-46-6) → methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate (909897-09-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / iron; AcOH / H₂O / 0.5 h / 50 °C

2: 91 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; iron; acetic acid; In dichloromethane; water;

DOI:10.1016/j.bmc.2006.05.076

Reference yield:

p-nitrobenzotrifluoride (402-54-0) → methyl 4-{[2-{[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate (909897-09-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent / potassium tert-butoxide; ammonia; tert-butyl hydroperoxide / decane; tetrahydrofuran / 0.5 h / Heating

2: 89 percent / K₂CO₃ / acetone / 3 h / 50 °C

3: 85 percent / iron; AcOH / H₂O / 0.5 h / 50 °C

4: 91 percent / pyridine / CH₂Cl₂ / 4 h / 20 °C

With pyridine; tert.-butylhydroperoxide; potassium tert-butylate; ammonia; iron; potassium carbonate; acetic acid; In tetrahydrofuran; decane; dichloromethane; water; acetone;

DOI:10.1016/j.bmc.2006.05.076

upstream raw materials:

methyl 4-[(2-amino-5-(trifluoromethyl)phenoxy)methyl]benzoate

methyl 4-[(2-nitro-5-(trifluoromethyl)phenoxy)methyl]benzoate

p-nitrobenzotrifluoride

2-nitro-5-trifluoromethylphenol

Downstream raw materials:

methyl 4-{[2-{isobutyl[(1-methyl-1H-pyrrol-3-yl)sulfonyl]amino}-5-(trifluoromethyl)phenoxy]methyl}benzoate