(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Base Information

Chemical Name:(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid
CAS No.:1436854-96-4
Molecular Formula:C₂₃H₂₇ClN₂O₃
Molecular Weight:414.932
Hs Code.:

Synonyms:(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Chemical Property of (S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

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Technology Process of (S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

There total 17 articles about (S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1436855-94-5
(R)-4-benzyl-3-((S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

: 1436854-96-4
(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;

Reference yield: 62.0%

: (R)-4-benzyl-3-(2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

: 1436854-96-4
(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

: (R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: With lithium hydroxide monohydrate; dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 2h;

Reference yield:

: isopropyl 2-(4-ethoxy-4-oxobut-2-en-2-ylamino)-1-(4-methoxybenzyl)-4,5-dimethyl-1H-pyrrolo-3-carboxylate

: 1436854-96-4
(S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

Guidance literature:: Multi-step reaction with 13 steps

1.1: sodium ethanolate / ethanol / 18 h / Reflux

2.1: trichlorophosphate / dichloromethane / 4 h / 60 °C

3.1: diisobutylaluminium hydride / dichloromethane; toluene / 2 h / -78 °C / Inert atmosphere

4.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 6 h / 100 - 110 °C / Inert atmosphere

5.1: triethylamine; sulfur trioxide pyridine complex / dimethyl sulfoxide / 3 h / 10 - 25 °C

6.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

7.1: water; hydrogenchloride / 18 h / 100 °C

8.1: sulfuric acid / water / 18 h / Reflux

9.1: perchloric acid / dichloromethane / 4 h / 0 - 20 °C

10.1: potassium hydroxide; tetrabutylammomium bromide / dichloromethane / 10 h / 25 °C

11.1: sodium hydroxide; methanol / 18 h / 25 °C

12.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / 5 h / 35 °C

12.2: 1 h / 20 °C

13.1: dihydrogen peroxide; lithium hydroxide monohydrate / water; tetrahydrofuran / 2 h / 0 °C

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; perchloric acid; lithium hydroxide monohydrate; sulfuric acid; tetrabutylammomium bromide; water; dihydrogen peroxide; sodium ethanolate; sulfur trioxide pyridine complex; diisobutylaluminium hydride; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; zinc(II) iodide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene; 4.1: |Suzuki Coupling;