C₄₈H₅₆N₈O₈

Base Information

Chemical Name:C₄₈H₅₆N₈O₈
CAS No.:888970-74-9
Molecular Formula:C₄₈H₅₆N₈O₈
Molecular Weight:873.021
Hs Code.:

C<sub>48</sub>H<sub>56</sub>N<sub>8</sub>O<sub>8</sub>

Synonyms:C₄₈H₅₆N₈O₈

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Chemical Property of C₄₈H₅₆N₈O₈

Chemical Property:

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Technology Process of C₄₈H₅₆N₈O₈

There total 12 articles about C₄₈H₅₆N₈O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1321595-03-2
C₄₈H₅₈N₈O₉*ClH

: 888970-74-9
C₄₈H₅₆N₈O₈

Guidance literature:: C₄₈H₅₈N₈O₉*ClH; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.tet.2011.06.032

Reference yield:

: 1048653-48-0
C₁₁H₁₅NO₂*ClH

: 888970-74-9
C₄₈H₅₆N₈O₈

Guidance literature:: Multi-step reaction with 8 steps

1.1: HATU / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

1.2: 36 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 8 h / 20 °C / 760.05 Torr

3.1: HATU / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

3.2: 6 h / 20 °C / Inert atmosphere

3.3: 18 h / 20 °C / Inert atmosphere

4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 20 °C / 760.05 Torr

5.1: HATU / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

5.2: 8 h / 20 °C / Inert atmosphere

5.3: 20 °C / Inert atmosphere

6.1: sodium hydroxide / water; isopropyl alcohol / 5 h / 0 - 20 °C

6.2: 0 °C / pH 4

7.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr

8.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

8.2: 48 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/j.tet.2011.06.032

Reference yield:

: 122-00-9
para-methylacetophenone

: 888970-74-9
C₄₈H₅₆N₈O₈

Guidance literature:: Multi-step reaction with 11 steps

1.1: ammonium hydroxide / ethanol / 4 h / 60 - 65 °C

1.3: Auto-seeded programmed polythermic preferential crystallization; Resolution of racemate

2.1: sodium hydroxide / water / 72 h / Reflux

3.1: thionyl chloride / -15 °C / Reflux

3.2: 2 h / 20 °C

4.1: HATU / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

4.2: 36 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 8 h / 20 °C / 760.05 Torr

6.1: HATU / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

6.2: 6 h / 20 °C / Inert atmosphere

6.3: 18 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; isopropyl alcohol / 20 °C / 760.05 Torr

8.1: HATU / tetrahydrofuran / 0.17 h / 0 °C / Inert atmosphere

8.2: 8 h / 20 °C / Inert atmosphere

8.3: 20 °C / Inert atmosphere

9.1: sodium hydroxide / water; isopropyl alcohol / 5 h / 0 - 20 °C

9.2: 0 °C / pH 4

10.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 760.05 Torr

11.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.17 h / 20 °C

11.2: 48 h / 20 °C

With hydrogenchloride; ammonium hydroxide; thionyl chloride; palladium 10% on activated carbon; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; HATU; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Bucherer-Bergs reaction;
DOI:10.1016/j.tet.2011.06.032