N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

Base Information

Chemical Name:N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester
CAS No.:164413-00-7
Molecular Formula:C₂₉H₃₈N₄O₅S₂
Molecular Weight:586.777
Hs Code.:

Synonyms:N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

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Chemical Property of N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

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Technology Process of N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

There total 12 articles about N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 18598-74-8
methyl L-isoleucinate hydrochloride

: 164412-48-0
2-Butyl-5-methylsulfanyl-3-(2'-sulfamoylbiphenyl-4-ylmethyl)-3H-imidazole-4-carboxylic acid

: 164413-00-7
N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; for 16h; Ambient temperature;
DOI:10.1021/jm00013a013

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 164413-00-7
N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

2: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

3: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

4: 81 percent / conc. HCl / ethanol / 2 h / Heating

5: 62 percent / 2N NaOH / ethanol / 36 h / Ambient temperature

6: 51 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / ethyl acetate / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013

Reference yield:

: 92748-09-9
2-bromobenzene-1-sulfonamide

: 164413-00-7
N-<<1-<<2'-(aminosulfonyl)(1,1'-biphenyl)-4-yl>methyl>-2-butyl-4-(methylthio)-1H-imidazol-5-yl>carbonyl>isoleucine methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / dimethylformamide / 2 h / Ambient temperature

2: 93 percent / aq. Na₂CO₃, triphenylphosphine, palladium acetate / ethanol; toluene / 4 h / Heating

3: 64 percent / N-bromosuccinimide, benzoyl peroxide / chlorobenzene / 1 h / 120 °C

4: K₂CO₃ / dimethylformamide / 45 h / 20 - 25 °C

5: 81 percent / conc. HCl / ethanol / 2 h / Heating

6: 62 percent / 2N NaOH / ethanol / 36 h / Ambient temperature

7: 51 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / ethyl acetate / 16 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; Perbenzoic acid; palladium diacetate; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; In ethanol; ethyl acetate; N,N-dimethyl-formamide; chlorobenzene; toluene;
DOI:10.1021/jm00013a013