N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Base Information

Chemical Name:N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate
CAS No.:142068-17-5
Molecular Formula:C₁₉H₂₀N₅O₆P
Molecular Weight:445.371
Hs Code.:

N<sup>6</sup>-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Synonyms:N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

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Chemical Property of N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Chemical Property:

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Technology Process of N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

There total 6 articles about N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Phosphorous acid (2S,5R)-5-(6-benzoylamino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl ester dimethyl ester

: 142068-17-5
N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Guidance literature:: With pyridine; iodine; In tetrahydrofuran; at -45 - -25 ℃; for 0.5h; Yield given;
DOI:10.1021/jm00093a003

Reference yield:

: 69504-16-1
N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)adenosine

: 142068-17-5
N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH, imidazole / 1.) THF, 45 min, 2.) THF, 30 min

2: tetrahydrofuran / 0.5 h

3: 91 percent / tri-n-butyltin hydride, azobisisobutyronitrile / toluene / 1 h / Heating

4: 87 percent / tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

5: 1H-tetrazole, pyridine / CH₂Cl₂ / 3 h

6: aq. I₂, pyridine / tetrahydrofuran / 0.5 h / -45 - -25 °C

With pyridine; 1H-imidazole; 1H-tetrazole; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; iodine; tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00093a003

Reference yield:

: 142068-15-3
N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine

: 142068-17-5
N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole, pyridine / CH₂Cl₂ / 3 h

2: aq. I₂, pyridine / tetrahydrofuran / 0.5 h / -45 - -25 °C

With pyridine; 1H-tetrazole; iodine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00093a003