(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

Base Information

Chemical Name:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester
CAS No.:109720-95-8
Molecular Formula:C₁₉H₃₀O₅Si
Molecular Weight:366.53
Hs Code.:

Synonyms:(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

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Chemical Property of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

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Technology Process of (S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

There total 5 articles about (S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1517-69-7
(R)-1-phenylethanol

: 91424-40-7
3-(tert-butyldimethylsilyloxy)glutaric anhydride

: 109720-94-7
(R)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

: 109720-95-8
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at -40 ℃; for 24h; Title compound not separated from byproducts;
DOI:10.1021/jm00393a030

Reference yield:

: 32328-03-3
diethyl 3-hydroxyglutarate

: 109720-95-8
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / imidazole / CH₂Cl₂ / 6 h / Ambient temperature

2: NaOH / methanol / 11.5 h / Ambient temperature

3: acetic anhydride / benzene / 1.33 h / Heating

4: Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 24 h / -40 °C

With 1H-imidazole; dmap; sodium hydroxide; acetic anhydride; triethylamine; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00393a030

Reference yield:

: 91424-39-4
3-[[(1,1-Dimethylethyl)dimethylsilyl]-oxy]pentanedioic acid,diethyl ester

: 109720-95-8
(S)-3-(tert-Butyl-dimethyl-silanyloxy)-pentanedioic acid mono-((R)-1-phenyl-ethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH / methanol / 11.5 h / Ambient temperature

2: acetic anhydride / benzene / 1.33 h / Heating

3: Et₃N, (N,N-dimethylamino)pyridine / CH₂Cl₂ / 24 h / -40 °C

With dmap; sodium hydroxide; acetic anhydride; triethylamine; In methanol; dichloromethane; benzene;
DOI:10.1021/jm00393a030