5-FLUORO-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL

Base Information

• Chemical Name: 5-FLUORO-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL
• CAS No.: 77180-90-6
• Molecular Formula: C30H23 F N2 O9
• Molecular Weight: 574.519
• Mol file: 77180-90-6.mol

Synonyms:5-FLUORO-1-(2’’, 3’’, 5’’-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL

Chemical Property of 5-FLUORO-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL

Chemical Property:

• PSA: 142.99000
• LogP: 2.88130

Purity/Quality:

97% ^*data from raw suppliers

5-FLUORO-1-(2', 3', 5'-TRI-O-BENZOYL-BETA-L-RIBOFURANOSYL)URACIL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-FLUORO-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL

There total 3 articles about 5-FLUORO-1-(2'', 3'', 5''-TRI-O-BENZOYL-β-L-RIBOFURANOSYL)URACIL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.9%

→ 1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-5-fluorouracil (77180-90-6)

Guidance literature:

Reference yield:

1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose (3080-30-6,6974-32-9,14215-97-5,16162-35-9,20822-87-1,21138-42-1,22249-15-6,22249-17-8,26287-72-9,53403-35-3,53403-36-4,57236-69-8,70832-64-3,99395-04-7,100101-51-7,109668-83-9,120019-54-7) + 5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine (17242-85-2) → 1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-5-fluorouracil (77180-90-6)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 ℃; for 6h;

DOI:10.1016/S0223-5234(01)01238-7

Reference yield:

(2S,3S,4S,5S)-2-((benzoyloxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl dibenzoate (1748-04-5,3258-14-8,4348-69-0,4348-70-3,20289-60-5,20397-91-5,77180-83-7,77180-84-8,77180-85-9,26287-73-0) → 1-(2,3,5-tri-O-benzoyl-β-L-ribofuranosyl)-5-fluorouracil (77180-90-6)

Guidance literature:

With fluorine; triethylamine; In acetic acid; for 1h; Ambient temperature;

DOI:10.1135/cccc19803217

upstream raw materials:

(2S,3S,4S,5S)-2-((benzoyloxy)methyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl dibenzoate

1-O-acetyl-2,3,5-tri-O-benzoyl-β-L-ribofuranose

5-fluoro-2,4-bis(trimethylsilyloxy)pyrimidine

Downstream raw materials:

1-(3'-O-benzyl-β-L-ribofuranosyl)-5-fluorouracil

C₃₀H₂₃FN₂O₈S