RA-VII

Base Information

• Chemical Name: RA-VII
• CAS No.: 137606-77-0
• Molecular Formula: C₄₀H₄₈N₆O₉
• Molecular Weight: 756.856
• Mol file: 137606-77-0.mol

Synonyms:RA-VII

Chemical Property of RA-VII

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of RA-VII

There total 13 articles about RA-VII which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

C40H50N6O10*ClH → RA-VII (137606-77-0)

Guidance literature:

With diphenylphosphoranyl azide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 4 ℃; for 48h;

DOI:10.1021/ja00133a010

Reference yield:

O-Methyltyrosine (6230-11-1) → RA-VII (137606-77-0)

Guidance literature:

Multi-step reaction with 10 steps

1: 91 percent

2: 88 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, NaHCO₃ / dimethylformamide / 10 h / 25 °C

3: 85 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 25 °C

4: 88 percent / EDCI, HOBt / dimethylformamide / 12 h / 25 °C

5: 90 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 25 °C

6: 86 percent / EDCI / CH₂Cl₂ / 4 h / 25 °C

7: 81 percent / tetrahydrofuran / 12 h / 50 °C

8: 92 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 25 °C

9: 100 percent / HCl / ethyl acetate / 1.) 0 deg C, 10 min, 2.) 25 deg C, 50 min

10: 65 percent / NaHCO₃, diphenylphosphoryl Azide / dimethylformamide / 48 h / 4 °C

With hydrogenchloride; lithium hydroxide; diphenylphosphoranyl azide; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja00133a010

Reference yield:

O-methyl-N-tert-butoxycarbonyl-L-tyrosine (53267-93-9) → RA-VII (137606-77-0)

Guidance literature:

Multi-step reaction with 9 steps

1: 88 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, NaHCO₃ / dimethylformamide / 10 h / 25 °C

2: 85 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 25 °C

3: 88 percent / EDCI, HOBt / dimethylformamide / 12 h / 25 °C

4: 90 percent / aq. LiOH / tetrahydrofuran; methanol / 3 h / 25 °C

5: 86 percent / EDCI / CH₂Cl₂ / 4 h / 25 °C

6: 81 percent / tetrahydrofuran / 12 h / 50 °C

7: 92 percent / aq. LiOH / tetrahydrofuran; methanol / 8 h / 25 °C

8: 100 percent / HCl / ethyl acetate / 1.) 0 deg C, 10 min, 2.) 25 deg C, 50 min

9: 65 percent / NaHCO₃, diphenylphosphoryl Azide / dimethylformamide / 48 h / 4 °C

With hydrogenchloride; lithium hydroxide; diphenylphosphoranyl azide; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ja00133a010

upstream raw materials:

O-Methyltyrosine

O-methyl-N-tert-butoxycarbonyl-L-tyrosine

L,L-N,N-dimethylcycloisodityrosine methyl ester

(S)-2-((R)-2-tert-butoxycarbonylamino-1-hydroxy-propylamino)-propionic acid