trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

Base Information

Chemical Name:trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide
CAS No.:142929-56-4
Molecular Formula:C₁₉H₂₄Cl₃NO₃
Molecular Weight:420.763
Hs Code.:

Synonyms:trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

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Chemical Property of trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

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Technology Process of trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

There total 7 articles about trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 142929-56-4
trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LDA / 1.) a) cyclohexane, -78 deg C, 30 min, b) cyclohexane, HMPA, -78 deg C, 15 min, 2.) cyclohexane, HMPA, 30 min

2: 89 percent / H₂ / 4percent Pd/C / ethanol / 258.6 Torr

3: 85 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

4: DIBAL / diethyl ether; toluene / 0.75 h / -78 °C

5: diethyl ether; toluene; tetrahydrofuran / 0.5 h / -78 - 0 °C

6: 1.) NaH / 1.) ether, 0 deg C, 30 min, 2.) ether, 1 h

7: xylene / 2 h / Heating

With hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; xylene;
DOI:10.1021/jm00094a002

Reference yield:

: 142929-53-1
ethyl α-<(phenylmethoxy)methyl>benzenepropanoate

: 142929-56-4
trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: 89 percent / H₂ / 4percent Pd/C / ethanol / 258.6 Torr

2: 85 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

3: DIBAL / diethyl ether; toluene / 0.75 h / -78 °C

4: diethyl ether; toluene; tetrahydrofuran / 0.5 h / -78 - 0 °C

5: 1.) NaH / 1.) ether, 0 deg C, 30 min, 2.) ether, 1 h

6: xylene / 2 h / Heating

With hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; toluene; xylene;
DOI:10.1021/jm00094a002

Reference yield:

: 107749-65-5
ethyl α-(hydroxymethyl)benzenepropanoate

: 142929-56-4
trichloro-N-<4-(phenylmethyl)-5-<(tetrahydro-2H-pyran-2-yl)oxy>-2(E)-pentenyl>acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 4 h / Ambient temperature

2: DIBAL / diethyl ether; toluene / 0.75 h / -78 °C

3: diethyl ether; toluene; tetrahydrofuran / 0.5 h / -78 - 0 °C

4: 1.) NaH / 1.) ether, 0 deg C, 30 min, 2.) ether, 1 h

5: xylene / 2 h / Heating

With pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; xylene;
DOI:10.1021/jm00094a002