(S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid

Base Information

• Chemical Name: (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid
• CAS No.: 1513888-66-8
• Molecular Formula: C₁₇H₂₅NO₅
• Molecular Weight: 323.389
• Mol file: 1513888-66-8.mol

Synonyms:(S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid

Chemical Property of (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid

There total 2 articles about (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

(S)-tyrosinol hydrochloride (87745-27-5,40829-04-7) + 1,8-octanedioic acid pentafluorophenyl ester → (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid (1513888-66-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ml400435h

Reference yield:

octane-1,8-dioic acid (505-48-6) → (S)-8-((1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)amino)-8-oxooctanoic acid (1513888-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide; tetrahydrofuran / Inert atmosphere

2: triethylamine / N,N-dimethyl-formamide; tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ml400435h

upstream raw materials:

(S)-tyrosinol hydrochloride

octane-1,8-dioic acid