2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine
• CAS No.: 1167572-25-9
• Molecular Formula: C₂₂H₁₆BrF₃N₂O₃S
• Molecular Weight: 525.346

Synonyms:2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Chemical Property of 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Chemical Property:

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Technology Process of 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine

There total 1 articles about 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-methyl-3-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167570-79-7) → 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167572-25-9)

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In acetonitrile; for 3h; Heating / reflux;

Reference yield: 68.0%

piperidine (110-89-4) + 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167572-25-9) → 3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-2-(piperidin-1-ylmethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167572-27-1)

Guidance literature:

In ethanol;

Reference yield: 60.0%

1H-imidazole (288-32-4) + 2-(bromomethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167572-25-9) → 2-(1H-imidazol-1-ylmethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine (1167572-24-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; for 1h;

upstream raw materials:

2-methyl-3-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

Downstream raw materials:

3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-2-(piperidin-1-ylmethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

2-(1H-imidazol-1-ylmethyl)-3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-8-(trifluoromethyl)imidazo[1,2-a]pyridine

3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-2-(pyrrolidin-1-ylmethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

3-{3-[3-(methylsulfonyl)phenoxy]phenyl}-2-(1,3-thiazolidin-3-ylmethyl)-8-(trifluoromethyl)imidazo[1,2-a]pyridine

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