(3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

• Chemical Name: (3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
• CAS No.: 1572245-83-0
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 1572245-83-0.mol

Synonyms:(3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Chemical Property of (3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 1 articles about (3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

methyl 4-formylvalerate (40630-06-6) + D-2-phenylglycinol (56613-80-0) → (3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine (1572245-83-0) + (3R,8S,8aR)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine (1572245-70-5)

Guidance literature:

With sodium sulfate; In diethyl ether; at 0 ℃; for 5h; Reagent/catalyst; Solvent; Time; Temperature;

DOI:10.1021/jo5002627

Reference yield: 55.0%

(3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine (1572245-83-0) → (R)-5-{[1(R)-2-hydroxy-1-phenylethyl]amino}-4-methyl-1-pentanol + (R)-1-[(1R)-2-hydroxy-1-phenylethyl]-3-methylpiperidine

Guidance literature:

With lithium amidotrihydridoborate; In tetrahydrofuran; hexane; at 40 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201501409

Reference yield: 20.0%

(3R,8R,8aS)-8-methyl-5-oxo-3-phenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine (1572245-83-0) → (R)-1-((R)-2-hydroxy-1-phenylethyl)-5-methylpiperidin-2-one

Guidance literature:

With triethylsilane; titanium tetrachloride; In dichloromethane; at 50 ℃; for 6h;

upstream raw materials:

methyl 4-formylvalerate

D-2-phenylglycinol