2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid

Base Information

• Chemical Name: 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid
• CAS No.: 879713-29-8
• Molecular Formula: C₂₃H₂₃O₄P
• Molecular Weight: 394.407
• Mol file: 879713-29-8.mol

Synonyms:2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid

Chemical Property of 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid

There total 5 articles about 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

benzylphosphinic acid (20394-86-9) + α-methylene-(1,1'-biphenyl)-4-propanoic acid (115369-84-1) → 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid (879713-29-8)

Guidance literature:

With bis-(trimethylsilyl)acetamide; at 70 ℃;

DOI:10.1002/anie.200500700

Reference yield:

(4-phenyl-benzyl)-malonic acid diethyl ester (37765-79-0) → 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid (879713-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 6.1 g / aq. NaOH / ethanol / 20 °C

2: 87 percent / Et₂NH / tetrahydrofuran; H₂O / Heating

3: 55 percent / bis(trimethylsilyl)acetamide / 70 °C

With sodium hydroxide; bis-(trimethylsilyl)acetamide; diethylamine; In tetrahydrofuran; ethanol; water;

DOI:10.1002/anie.200500700

Reference yield:

<(1,1'-biphenyl)-4-ylmethyl>propanedioic acid (115369-83-0) → 2-(benzyl-hydroxy-phosphinoylmethyl)-3-biphenyl-4-ylpropionic acid (879713-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Et₂NH / tetrahydrofuran; H₂O / Heating

2: 55 percent / bis(trimethylsilyl)acetamide / 70 °C

With bis-(trimethylsilyl)acetamide; diethylamine; In tetrahydrofuran; water;

DOI:10.1002/anie.200500700

upstream raw materials:

benzylphosphinic acid

α-methylene-(1,1'-biphenyl)-4-propanoic acid

(4-phenyl-benzyl)-malonic acid diethyl ester

<(1,1'-biphenyl)-4-ylmethyl>propanedioic acid