C₄₀H₄₅FO₁₀S

Base Information

Chemical Name:C₄₀H₄₅FO₁₀S
CAS No.:1373634-72-0
Molecular Formula:C₄₀H₄₅FO₁₀S
Molecular Weight:736.856
Hs Code.:

C<sub>40</sub>H<sub>45</sub>FO<sub>10</sub>S

Synonyms:C₄₀H₄₅FO₁₀S

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Chemical Property of C₄₀H₄₅FO₁₀S

Chemical Property:

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Technology Process of C₄₀H₄₅FO₁₀S

There total 10 articles about C₄₀H₄₅FO₁₀S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1373634-69-5
C₄₀H₄₇FO₁₀S

: 1373634-72-0
C₄₀H₄₅FO₁₀S

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/ol300672q

Reference yield:

: 1191256-12-8
C₂₅H₂₆O₇

: 1373634-72-0
C₄₀H₄₅FO₁₀S

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / 0 - 20 °C / Inert atmosphere

1.2: 0.67 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 0.17 h / 0 °C / Inert atmosphere

5.1: Crabtree's catalyst; hydrogen / dichloromethane / 0 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: chromium dichloride; manganese; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 4 h / 20 °C / Inert atmosphere

8.1: triethylsilane; triethylsilyl trifluoromethyl sulfonate / acetonitrile / 0.33 h / -40 °C / Inert atmosphere

9.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With chromium dichloride; triethylsilane; manganese; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; zirconocene dichloride; Crabtree's catalyst; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; water; hydrogen; triethylsilyl trifluoromethyl sulfonate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydrogencarbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol300672q

Reference yield:

: 1373634-46-8
diethyl (((3-fluorophenyl)sulfonyl)methyl)phosphonate

: 1373634-72-0
C₄₀H₄₅FO₁₀S

Guidance literature:: Multi-step reaction with 9 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran; toluene / 0.17 h / 0 - 20 °C / Inert atmosphere

1.2: 0.67 h / 20 °C / Inert atmosphere

2.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / dichloromethane / 1.5 h / 20 °C / Inert atmosphere

3.1: sodium periodate; sodium hydrogencarbonate / dichloromethane; water / 20 °C / Inert atmosphere

4.1: sodium tetrahydroborate / methanol / 0.17 h / 0 °C / Inert atmosphere

5.1: Crabtree's catalyst; hydrogen / dichloromethane / 0 °C / Inert atmosphere

6.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

7.1: chromium dichloride; manganese; zirconocene dichloride; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; lithium chloride / acetonitrile / 4 h / 20 °C / Inert atmosphere

8.1: triethylsilane; triethylsilyl trifluoromethyl sulfonate / acetonitrile / 0.33 h / -40 °C / Inert atmosphere

9.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 1 h / 20 °C / Inert atmosphere

With chromium dichloride; triethylsilane; manganese; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; zirconocene dichloride; Crabtree's catalyst; N-(2-((S)-4-isopropyl-4,5-dihydrooxazol-2-yl)-6-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)phenyl)benzenesulfonamide; water; hydrogen; triethylsilyl trifluoromethyl sulfonate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydrogencarbonate; Dess-Martin periodane; 4-methylmorpholine N-oxide; lithium chloride; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; toluene; acetonitrile;
DOI:10.1021/ol300672q