3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

Base Information

Chemical Name:3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine
CAS No.:1310950-07-2
Molecular Formula:C₂₀H₂₂ClNOS
Molecular Weight:359.92
Hs Code.:

Synonyms:3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

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Chemical Property of 3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

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Technology Process of 3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

There total 10 articles about 3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: (cyclopentylmethyl)(triphenyl)phosphonium iodide

: 1310947-45-5
(5-chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanone

: 1310950-07-2
3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

Guidance literature:: (cyclopentylmethyl)(triphenyl)phosphonium iodide; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere; Cooling with ice;

(5-chloro-6-methoxypyridin-2-yl)[4-(methylsulfanyl)phenyl]methanone; In tetrahydrofuran; at 20 ℃; for 1h; Cooling with ice; Inert atmosphere;

Reference yield:

: 1310949-27-9
5-chloro-2-(ethoxycarbonyl)pyridine 1-oxide

: 1310950-07-2
3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic anhydride / N,N-dimethyl-formamide / 1.33 h / 50 °C / Cooling with ice

1.2: Cooling with ice

2.1: silver carbonate / chloroform / 7 h / 70 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / Cooling with ice

4.1: manganese(IV) oxide / chloroform / 1 h / 60 °C

5.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

5.2: 1 h / -78 °C / Inert atmosphere

6.1: manganese(IV) oxide / chloroform / 1 h / 65 °C

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

7.2: 1 h / 20 °C / Cooling with ice; Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; n-butyllithium; silver carbonate; trifluoroacetic anhydride; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;

Reference yield:

: 1211527-87-5
5-chloro-6-methoxypyridin-2-carbaldehyde

: 1310950-07-2
3-chloro-6-{(E)-2-cyclopentyl-1-[4-(methylsulfanyl)phenyl]ethenyl}-2-methoxypyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

1.2: 1 h / -78 °C / Inert atmosphere

2.1: manganese(IV) oxide / chloroform / 1 h / 65 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere; Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice; Inert atmosphere

With manganese(IV) oxide; n-butyllithium; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;