1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Base Information

Chemical Name:1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine
CAS No.:219553-50-1
Molecular Formula:C₂₃H₃₃N₃O₄
Molecular Weight:415.533
Hs Code.:

Synonyms:1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

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Chemical Property of 1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

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Technology Process of 1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

There total 6 articles about 1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 109-78-4
3-Hydroxypropionitrile

: 219553-44-3
1-<3-(N-tert-butoxycarbonylamino)propyl>-4-phenylpiperidine-4-carboxylic acid

: 219553-50-1
1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; for 16h; Heating;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 219553-50-1
1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 1 N aq. NaOH / dioxane / 12 h / 0 - 20 °C

2: 99 percent / DMAP, EDC / CH₂Cl₂ / 16 h / Heating

With dmap; sodium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane;

Reference yield:

: 77-17-8
Normeperidine

: 219553-50-1
1-N-(tert-butoxycarbonyl)-3-<4-(2-cyanoethoxycarbonyl)-4-phenylpiperidin-1-yl>propylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 83.3 percent / K₂CO₃, KI / dioxane / 24 h / Heating

2: 99 percent / 6 N aq. HCl / 3 h / Heating

3: 83 percent / 1 N aq. NaOH / dioxane / 12 h / 0 - 20 °C

4: 99 percent / DMAP, EDC / CH₂Cl₂ / 16 h / Heating

With hydrogenchloride; dmap; sodium hydroxide; potassium carbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; In 1,4-dioxane; dichloromethane;