6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

Base Information

Chemical Name:6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol
CAS No.:1393578-94-3
Molecular Formula:C₂₄H₂₂N₂O₃
Molecular Weight:386.45
Hs Code.:

Synonyms:6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

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Chemical Property of 6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

Chemical Property:

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Technology Process of 6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

There total 5 articles about 6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1393578-93-2
4-((6-bromopyridin-2-yl)methyl)-6,7-dimethoxy-1-methylisoquinolin-3-ol

: 98-80-6
phenylboronic acid

: 1393578-94-3
6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; at 140 ℃; for 0.416667h; Microwave irradiation;

Reference yield:

: 15964-79-1
methyl (3,4-dimethoxyphenyl)acetate

: 1393578-94-3
6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: perchloric acid / water / 1.25 h / 0 - 20 °C / Inert atmosphere

2: ammonium hydroxide / water / 1 h / 20 °C

3: potassium hydroxide / toluene; water / 1.83 h / 150 °C / Microwave irradiation

4: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.42 h / 140 °C / Microwave irradiation

With ammonium hydroxide; perchloric acid; sodium carbonate; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; toluene;

Reference yield:

: 16535-98-1
3-hydroxy-6,7-dimethoxy-1-methylisoquinoline

: 1393578-94-3
6,7-dimethoxy-1-methyl-4-((6-phenylpyridin-2-yl)methyl)isoquinolin-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / toluene; water / 1.83 h / 150 °C / Microwave irradiation

2: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; ethanol; water / 0.42 h / 140 °C / Microwave irradiation

With sodium carbonate; potassium hydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,2-dimethoxyethane; ethanol; water; toluene;