(S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol

Base Information

• Chemical Name: (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol
• CAS No.: 328969-77-3
• Molecular Formula: C₂₀H₂₇NO₃
• Molecular Weight: 329.439
• Mol file: 328969-77-3.mol

Synonyms:(S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol

Chemical Property of (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol

There total 1 articles about (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

vinyl acetate (108-05-4,9003-20-7) + rac-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol (328969-74-0) → (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol (328969-77-3) + (S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol acetate + (R)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol acetate

Guidance literature:

With Pseudomonas cepacia lipase; In various solvent(s); at 40 ℃; for 24h;

DOI:10.1016/S0957-4166(00)00428-6

Reference yield: 56.0%

(S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol (328969-77-3) → (R)-N-(benzyloxycarbonyl)-2-(1-adamantyl)glycine

Guidance literature:

With ruthenium trichloride; sodium periodate; In tetrachloromethane; water; acetonitrile; at 20 ℃;

DOI:10.1016/S0957-4166(00)00428-6

Reference yield:

(S)-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol (328969-77-3) → R-amino-(1-adamantanyl)acetic acid (59768-71-7,60256-21-5,95853-35-3,100926-41-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 56 percent / ruthenium(III) chloride dihydrate; sodium periodate / CCl₄; acetonitrile; H₂O / 20 °C

2: H₂ / 10 percent Pd/C / methanol / 1520 Torr

With ruthenium trichloride; sodium periodate; hydrogen; palladium on activated charcoal; In methanol; tetrachloromethane; water; acetonitrile;

DOI:10.1016/S0957-4166(00)00428-6

upstream raw materials:

vinyl acetate

rac-N-(benzyloxycarbonyl)-2-(1-adamantyl)-2-aminoethanol

Downstream raw materials:

R-amino-(1-adamantanyl)acetic acid

Refernces