N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

Base Information

Chemical Name:N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide
CAS No.:1196537-76-4
Molecular Formula:C₂₁H₂₆N₄O₃
Molecular Weight:382.462
Hs Code.:

Synonyms:N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

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Chemical Property of N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

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Technology Process of N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

There total 3 articles about N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.2%

: 253870-02-9
5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid

: 1152838-28-2
C₁₃H₁₉N₃O

: 1196537-76-4
N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

Guidance literature:: 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 0 ℃; for 1.5h;

C₁₃H₁₉N₃O; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 18471-40-4,60652-45-1,114715-38-7,114715-39-8
1-Benzyl-3-aminopyrrolidine

: 1196537-76-4
N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 0 - 20 °C

2.1: ammonia / water; methanol / 45 °C

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 0 °C

3.2: 20 °C

With ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 939758-04-0
C₁₃H₁₇ClN₂O

: 1196537-76-4
N-{2-[(1-benzylpyrrolidin-3-yl)amino]-2-oxoethyl}-5-formyl-2,4-dimethyl-1H-pyrrole-3-formamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: ammonia / water; methanol / 45 °C

2.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / benzotriazol-1-ol / N,N-dimethyl-formamide / 1.5 h / 0 °C

2.2: 20 °C

With ammonia; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol; In methanol; water; N,N-dimethyl-formamide;