1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane

Base Information

• Chemical Name: 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane
• CAS No.: 151915-06-9
• Molecular Formula: C₃₀H₃₅N₃O₄S
• Molecular Weight: 533.692
• Mol file: 151915-06-9.mol

Synonyms:1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane

Chemical Property of 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane

There total 3 articles about 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + 1-<<(2-mesitylene)sulfonyl>amino>-3-(benzylamino)propane (151915-05-8) → 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane (151915-06-9)

Guidance literature:

With sodium carbonate; lithium iodide; In butan-1-ol; at 80 ℃; for 24h;

DOI:10.1021/jm00072a020

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane (151915-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 10percent aq. NaOH / CH₂Cl₂ / 1.5 h / 0 °C

2: 75 percent / Na₂CO₃, LiI / butan-1-ol / 24 h / 80 °C

With sodium hydroxide; sodium carbonate; lithium iodide; In dichloromethane; butan-1-ol;

DOI:10.1021/jm00072a020

Reference yield:

N-benzyl-1,3-diaminopropane (13910-48-0) → 1-phthalimido-4-(N-benzyl)-7-<<(2-mesitylene)sulfonyl>amino>-4-azaheptane (151915-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / 10percent aq. NaOH / CH₂Cl₂ / 1.5 h / 0 °C

2: 75 percent / Na₂CO₃, LiI / butan-1-ol / 24 h / 80 °C

With sodium hydroxide; sodium carbonate; lithium iodide; In dichloromethane; butan-1-ol;

DOI:10.1021/jm00072a020

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

1-<<(2-mesitylene)sulfonyl>amino>-3-(benzylamino)propane

2-mesitylenesulphonyl chloride

N-benzyl-1,3-diaminopropane

Downstream raw materials:

1-phthalimido-4-(N-benzyl)-8--11-amino-4,8-diazaundecane

{3-[(3-Amino-propyl)-benzyloxycarbonyl-amino]-propyl}-ethyl-carbamic acid benzyl ester

1-amino-4-[N-(2-mesitylene)sulfonyl]-7-{N-ethyl-N-[(2-mesitylene)sulfonyl]}amino-4-azaheptane

[3-(Benzyloxycarbonyl-ethyl-amino)-propyl]-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamic acid benzyl ester