methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate

Base Information

• Chemical Name: methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate
• CAS No.: 597558-93-5
• Molecular Formula: C₂₅H₂₁N₃O₄
• Molecular Weight: 427.459

Synonyms:methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate

Chemical Property of methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate

Chemical Property:

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Technology Process of methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate

There total 2 articles about methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

N-benzyl-2-phenylglycine methyl ester (78907-06-9) + 2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde (17481-62-8) → methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate (597558-93-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 12h; Heating;

DOI:10.1016/S0040-4020(03)00657-4

Reference yield:

N-benzyl-2-phenylglycine methyl ester (78907-06-9) + 2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde (17481-62-8) → C10H5N3(O)C7H7(OH)(CO2CH3)(C6H5) + methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate (597558-93-5)

Guidance literature:

With triethylamine;

Reference yield: 100.0%

methyl N-benzyl-N-(3-formyl-4-oxo-4H-pyrido[1,2-a]pyrimidin-2-yl)phenylglycinate (597558-93-5) → 2-phenylpyrrolo[2,3-d]pyrido[1,2-a]pyrimidin-4(1H)-one

Guidance literature:

With xylene; at 70 ℃; Heating;

upstream raw materials:

N-benzyl-2-phenylglycine methyl ester

2-chloro-4-oxo-4H-pyrido<1,2-a>pyrimidine 3-carboxaldehyde

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