1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

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Chemical Name:1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate
CAS No.:1361218-32-7
Molecular Formula:C₂HF₃O₂*C₂₃H₂₀F₆N₂O₃S₂
Molecular Weight:664.57
Hs Code.:

Synonyms:1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

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Chemical Property of 1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

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Technology Process of 1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

There total 3 articles about 1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361218-33-8
2-(3-bromo-4-(4-(thiophenylsulfonyl)piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

: 76-05-1
trifluoroacetic acid

: 98-80-6
phenylboronic acid

: 1361218-32-7
1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

Guidance literature:: 2-(3-bromo-4-(4-(thiophenylsulfonyl)piperazinyl)phenyl)-1,1,1,3,3,3-hexafluoro-2-propanol; phenylboronic acid; With caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; water; at 100 ℃; for 0.166667h; microwave irradiation;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 909418-64-0
1,1,1,3,3,3-hexafluoro-2-(4-(piperazin-1-yl)phenyl)-propan-2-ol

: 1361218-32-7
1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; acetic acid / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

3: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 0.17 h / 100 °C / microwave irradiation

With bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: C₁₃H₁₃BrF₆N₂O

: 1361218-32-7
1,1,1,3,3,3-hexafluoro-2-(6-(4-(2-thiophenylsulfonyl)-1-piperazinyl)-3-biphenylyl)-2-propanol trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 20 °C

2: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 0.17 h / 100 °C / microwave irradiation

With caesium carbonate; N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; dichloromethane; water;